{"product_id":"foxo4","title":"FOXO4-DRI","description":"\u003cp dir=\"auto\"\u003e\u003cstrong\u003eProduct Description\u003c\/strong\u003e FOXO4-DRI is a cell-permeable senolytic peptide designed to selectively induce apoptosis in senescent cells. Supplied as ≥98% pure lyophilized powder (HPLC\/MS verified), it is intended for laboratory studies on cellular senescence, aging, and age-related pathology.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cstrong\u003eKey Research Mechanism\u003c\/strong\u003e FOXO4-DRI disrupts the interaction between FOXO4 and p53 in senescent cells. This interference releases p53 from its protective binding, promoting nuclear exclusion of p53 and triggering selective apoptosis in senescent (\"zombie\") cells while sparing healthy ones.\u003c\/p\u003e\n\u003cp dir=\"auto\"\u003e\u003cstrong\u003ePrimary Research Areas\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul dir=\"auto\"\u003e\n\u003cli\u003eSenolytic applications and clearance of senescent cells\u003c\/li\u003e\n\u003cli\u003eAge-related decline and longevity pathway studies\u003c\/li\u003e\n\u003cli\u003eTissue rejuvenation (e.g., muscle, cartilage, vascular, and testicular models)\u003c\/li\u003e\n\u003cli\u003eSenescence-associated inflammation and disease modeling\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp dir=\"auto\"\u003e\u003cstrong\u003eIntended Use\u003c\/strong\u003e For \u003cem\u003ein vitro\u003c\/em\u003e and \u003cem\u003ein vivo\u003c\/em\u003e research only. Not for human or veterinary use. This product is sold strictly for scientific and laboratory investigation. Researchers must follow all institutional and regulatory guidelines. Not evaluated by the FDA.\u003c\/p\u003e","brand":"My Store","offers":[{"title":"5 mg","offer_id":40686993145985,"sku":null,"price":99.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0596\/2652\/0705\/files\/FOXO4.webp?v=1779950283","url":"https:\/\/axisbiotech.com\/products\/foxo4","provider":"AxisBiotech+","version":"1.0","type":"link"}