FOXO4-DRI

Product Description FOXO4-DRI is a cell-permeable senolytic peptide designed to selectively induce apoptosis in senescent cells. Supplied as ≥98% pure lyophilized powder (HPLC/MS verified), it is intended for laboratory studies on cellular senescence, aging, and age-related pathology.

Key Research Mechanism FOXO4-DRI disrupts the interaction between FOXO4 and p53 in senescent cells. This interference releases p53 from its protective binding, promoting nuclear exclusion of p53 and triggering selective apoptosis in senescent ("zombie") cells while sparing healthy ones.

Primary Research Areas

• Senolytic applications and clearance of senescent cells
• Age-related decline and longevity pathway studies
• Tissue rejuvenation (e.g., muscle, cartilage, vascular, and testicular models)
• Senescence-associated inflammation and disease modeling

Intended Use For in vitro and in vivo research only. Not for human or veterinary use. This product is sold strictly for scientific and laboratory investigation. Researchers must follow all institutional and regulatory guidelines. Not evaluated by the FDA.