SLU-PP-332

Product Description SLU-PP-332 is a potent pan-estrogen-related receptor (ERR) agonist that activates ERRα, ERRβ, and ERRγ (with highest potency at ERRα, EC₅₀ ≈ 98 nM). Supplied as ≥98% pure lyophilized powder (HPLC/MS verified), it is designed for laboratory studies on mitochondrial biogenesis, energy metabolism, exercise mimetics, and metabolic regulation.

Key Research Mechanism SLU-PP-332 binds to ERR nuclear receptors, stabilizing their active conformation and enhancing recruitment of coactivators such as PGC-1α. This triggers gene expression programs that mimic aerobic exercise, increasing mitochondrial function, fatty acid oxidation, oxidative phosphorylation, and cellular energy expenditure.

Primary Research Areas

• Exercise mimetic effects and mitochondrial biogenesis in muscle cells
• Metabolic health & obesity models (reduced fat mass and improved glucose tolerance in preclinical studies)
• Energy expenditure, fatty acid oxidation, and endurance pathway research
• Mitochondrial efficiency and age-related metabolic decline

Intended Use For in vitro and in vivo research only. Not for human or veterinary use. This product is sold strictly for scientific and laboratory investigation. Researchers must follow all institutional and regulatory guidelines. Not evaluated by the FDA.